(Major) Depressive Disorder depression
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Fulfilling the criteria for major depression according to DSM-IV-TR criteria Informed consent. Regarded by the treating physician to have competence of judgement Age 18-50 years
Exclusion criteria
Exclusion criteria: Current use of any medication (patients must be drug-free for three weeks) except use of benzodiazepines. Drug or alcohol abuse in the past year Prior cardiovascular disease, brain disease (including former traumatic contusion) Evidence of any general medical disease, e.g. significant kidney or liver disease Abnormalities at clinical neurological examination Pregnancy ;(healthy controls): presence in the past of any psychiatric diagnosis, or the presence of a psychiatric disturbance in first-degree relatives of the subject, will be used as an exclusion criterion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome variables will be the distribution volume, the binding potential and receptor density in the brain. Our hypothesis is that the number of sigma-receptors will be increased in persons with a depressive disorder. | — |
Countries
Netherlands
Outcome results
None listed