abnormalities of the small blood vessels inside the brain and the relationship with attention concentration and memory Microvascular disease of the brain and cognitive functioning
Conditions
Interventions
None listed
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: age 18-45 years right-handedness: Dutch as a native language
Exclusion criteria
Exclusion criteria: alcohol abuse which is defined as more than 20 gram of alcohol per day, (history of) use of MDMA, cocaine, heroin, methylphenidate, current regular use of cannabis, or history of regular use on a daily basis for at least 5 years, current use of benzodiazepines, non-selective beta blockers, oral steroids (>7.5 mg/day), psychiatric disorder warranting psychotropic treatment (e.g. tranquillisers, anti-depressants) anaemia or thyroid dysfunction, history of severe head trauma accompanied by loss of consciousness, stroke epilepsy pregnancy Parkinson*s disease inability to undergo MRI (claustrophobia, metal implants, BMI>35), visual acuity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint: Cognitive function (neuropsychological performance, specifically attention, mental flexibility and executive functioning) at baseline and at follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints: Brain volume, white matter lesions at baseline and at follow-up | — |
Countries
Netherlands
Outcome results
None listed