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Regulation of apoptosis in cultured airway epithelial cells of infants

Regulation of apoptosis in cultured airway epithelial cells of infants - Apoptosis in the lung

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
NL-OMON
Registry ID
NL-OMON29743
Enrollment
30
Registered
2006-05-16
Start date
2006-06-01
Completion date
Unknown
Last updated
2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Academisch Medisch Centrum
Lead Sponsor

Eligibility

Age
2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Age: 2 - 24 months. Endotracheally intubated for elective surgery for non-pulmonary disorders at the Academic Medical Center in Amsterdam.

Exclusion criteria

Exclusion criteria: Age under 2- or above 24 months. History of pulmonary disorder. No permission form parents or guardian.

Design outcomes

Primary

MeasureTime frame
Evidence for apoptosis: caspase-3 activity, annexin-V binding and morphological studies. Apoptotic pathways: RNA of the Bcl-2 and IAP family of pro- and anti-apoptotic factors, RNA and protein analysis of Fas/FasL and caspase-8 and -9 activity.—

Secondary

MeasureTime frame
none—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)