Anemia in Chronic Heart Failure due to circulation factors

Anemia in Chronic Heart Failure due to circulation factors - Anemia in Chronic Heart Failure due to circulation factors

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29720

Enrollment

Registered

2006-09-12

Start date

2006-10-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anemia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: a. Male or female b. Between 50-90 years of age c. Willing to provide written informed consent

Exclusion criteria

Exclusion criteria: f. Unstable medical condition g. Presence of other serious medical conditions h. Renal failure (kreatinin > 150 µmol/l) i. Concomitant inflammatory or malignant disease j. *Wilsonbekwaamheid* k. Chronic steroid use l. Recent blood transfusion m. Currently receiving EPO-treatment

Design outcomes

Primary

Measure	Time frame
Difference in proliferation, G2/G0 ratio and numbers of apoptotic cells after EPO-stimulation of UT7-EPO cells after 3 days in culture.	—

Secondary

Measure	Time frame
•Difference between anaemic and non-anaemic CHF patients in plasma ACE-activity, Ac-SDKP, EPO, high-sensitivity CRP, IFN-gamma, IL-1, and TNF-alpha levels. •Correlation between UT7-EPO cell proliferation and plasma ACE-activity, Ac-SDKP, EPO, high-sensitivity CRP, IFN-gamma, IL-1, and TNF-alpha levels. •Difference in proliferation between untreated and inhibitory antibody pre-treated serum	—

Countries

Netherlands

Outcome results