Intracerebral hemorrhage
Conditions
Interventions
None listed
Sponsors
Radboudumc
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age = 18 years; 2. Supratentorial non-traumatic ICH confirmed by CT, without a confirmed causative lesion on admission CT-angiography or other known underlying lesion; 3. Minimal haemorrhage volume of 10mL; 4. Inclusion within 24 hours after symptom onset; 5. Patient’s or legal representative’s informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe infection at admission, requiring antibiotic treatment; 2. Use of immunosuppressive or immune-modulating therapy at admission (see appendix A ); 3. Pre-stroke modified Rankin Scale score = 3 4. Severe ICH, unlikely to survive the first 72 hours (defined as Glasgow Coma Scale score < 6 at time of consent); 5. Pregnancy or breast-feeding; 6. Standard contraindications to MRI; 7. Administration of a radionuclide within 10 physical half-lives prior to study enrolment. 8. Known prior allergic reaction to gadolinium contrast or one of the constituents of its solution for administration; 9. Severe renal impairment (eGFR <30ml/min/1.73m); 10. Planned neurosurgical haematoma evacuation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is perihematomal oedema on MRI at day 7±1, which will be correlated with perihematomal uptake of 18F-DPA-714 on PET imaging at day 3±1 as a measure of neuroinflammation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are the association between and the perihematomal uptake of 18F-DPA-714 on PET imaging at day 3±1 and blood barrier leakage Ktrans as measured with DCE-MRI on day 7±1. Furthermore the correlation with serum inflammation markers (comparing day 1, 3 and 7 to baseline) will be assessed. | — |
Contacts
Public ContactMaaike Cliteur
Radboudumc Nijmegen
Outcome results
None listed