Ventilation with Lower Tidal Volumes as Compared to Traditional Tidal Volumes of Patients not Suffering from Acute Lung Injury.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON29661

Enrollment

200

Registered

2005-08-27

Start date

2005-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Need for prolonged mechanical ventilation.

Interventions

Patients are randomly assigned to receive mechanical ventilation involving either traditional VT (10 ml/kg PBW) or lower VT (6 ml/kg PBW). All patients will undergo a minilavage every second day, pre

Eligibility

Inclusion criteria

Inclusion criteria: Patients who are intubated and expected to receive mechanical ventilation for > 72 hours are eligible for the study if they do not suffer from ALI/ARDS, according to the American/European consensus criteria.

Exclusion criteria

Exclusion criteria: 1. > 36 hours after start of MV; 2. Are under 18; 3. Participation in other trials; 4. Pregnancy; 5. Increased uncontrolable intracranial pressure; 6. Severe chronic respiratory disease (daily medication); 7. Pneumonia; 8. Use of corticosteroids (systemic or local) or other immunosuppressive agents; 9. Pulmonary thrombo-embolism; 10. After pneumonectomy or lobectomy; 11. Previous randomisation in this study.

Design outcomes

Primary

Measure	Time frame
1. Local inflammatory responses; 2. Local Fibrin turnover; 3. Systemic levels of biomarkers of lung injury.	—

Secondary

Measure	Time frame
Late ALI/ARDS.	—

Contacts

Public ContactM.J. Schultz

Meibergdreef 9

m.j.schultz@amc.uva.nl+31 (0)20 5669111

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)