Cervical intraepithelial neoplasia (CIN), Cervix cancer
Conditions
Interventions
This randomized-controlled trial is coordinated by the VU University medical center (VUmc) and performed in collaboration with UMCN, the screening organizations Midden-West and Oost and RIVM. In the r
Sponsors
VU University Medical Center, Department of Pathology, Univerisity Medical Center Nijmegen, Comprehensive Cancer Center (IKA) Amsterdam , National Institute for Public Health and the Environment (RIVM),
Eligibility
Inclusion criteria
Inclusion criteria: 1. Women invited for the cervical cancer screening program in 2007 (ages 30-60 years), who did not respond to an initial invitation and a recall after 3-6 months; 2. Women should reside in the regions covered by district health authorities of Noord-Holland, Flevoland, Utrecht and Gelderland (in the Netherlands).
Exclusion criteria
Exclusion criteria: 1. Not in the population based screening program, i.e. ages under 30 years, or over 60 years; 2. Actively responded to the invitation or recall of the cervical screening program by undergoing a cervical smear at the general practitioner; 3. Under follow-up by gynaecologist for previous abnormal cytology, and/or CIN3 lesion or worse less than 2 years before inclusion; 4. Current pregnancy; 5. Status after hysterectomy or amputation of the portio.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of CIN 2+ and CIN 3+ lesions in both triage strategies. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Participation rate of hrHPV positive women in both triage strategies; 2. Comparison of the cost-effectiveness between both triage strategies. | — |
Contacts
Public ContactV.M.J. Verhoef
Outcome results
None listed