Adult patients undergoing elective open or laparoscopic abdominal surgery.
Conditions
Interventions
Standard anaesthetic management guided by mitoPO2 monitoring.
Sponsors
Amsterdam University Medical Centres, Location AMC
Eligibility
Inclusion criteria
Inclusion criteria: • Patients are at least 18 years old • Patients undergo elective open or laparoscopic abdominal surgery with an expected minimal total incision size of 5 cm • Patients are able and willing to give written informed consent
Exclusion criteria
Exclusion criteria: • Known photodermatoses of varying pathology and frequency • Mitochondrial disease • Porphyria • Skin lesions on the upper arm which impede measurements • Hypersensitivity to the active substance or the 5-ALA medicated plaster material • Emergency surgery • Reoperation for complications from recent surgery (within last three months) • Participation in another study with interference with this study • Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean mitoPO2 during abdominal surgery over time | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are the number, type and the respective effect of interventions that results in an increase of mitoPO2 after notification in which mitoPO2 aids decision making on anaesthetic management, the proportion of these incidences that were associated with a change in mitoPO2 and the proportion of patients this occurs in, the average cumulative duration of mitoPO2 below individual baseline value, the association of mitoPO2 with conventional hemodynamic monitoring measures and the SSI incidence after 30 days follow-up. | — |
Contacts
Public ContactRick Hulskes
Amsterdam UMC, location AMC
Outcome results
None listed