NAFLD
Conditions
Interventions
high-intensity interval training on a cycle ergometer (Hallsworth et al., 2015).
Sponsors
EU
Eligibility
Inclusion criteria
Inclusion criteria: - Diagnosis of steatosis on transient elastography, conventional ultrasound, magnetic resonance imaging, computed tomography, liver biopsy, or identified as steatotic subject by fatty liver index (FLI) algorithm which is based on waist circumference, body mass index, and levels of triglyceride and ?-glutamyltransferase - 18-70 years of age - BMI < 40 kg/m2
Exclusion criteria
Exclusion criteria: - Acute illness or current evidence of acute or chronic inflammatory or infective diseases - Abusive alcohol use (> 20 IU/week for men, > 14 IU/week for women) - Smoking - Diagnosed liver cirrhosis and/or hepatocellular carcinoma - Diagnosed cardiorespiratory, neurological or musculoskeletal disease - Diagnosed insulin or GLP-1 agonist treated type 2 diabetes or type 1 diabetes - Hepatitis B and/or C or auto-immune hepatitis - Wilsons disease/alpha-1-antitripsine deficiency - Hemochromatosis - Hypothyroidism - Lipoatrophy - Bleeding disorder or anti-coagulant use which cannot be temporarily discontinued - Not able or willing to undergo MRI (for example claustrophobia, ICD, pacemaker) - Diagnosed depression or any mental illness rendering the patients unable to understand the nature, scope and possible sequences of the study - Any participation in regular exercise and/or diet program more than 2 times per week in the 3 months prior to recruitment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are changes in NAFLD liver histology and gene expression in relation to oral and gut microbiota composition changes upon 12 weeks of exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| Second changes in other organs involved upon exercise driven metabolic fitness including subcutaneous adipose tissue and muscle gene expression (RNA-sequencing) and histology, in relation to glucose metabolism (freestyle libre) and metabolites in plasma and urine will be studied. Finally, the relative contribution to NAFLD and glucose metabolism of the different organs (liver, adipose tissue and muscle) upon exercise will be studied. | — |
Contacts
Public ContactMax Nieuwdorp
AMC
Outcome results
None listed