Does the addition of recLH (Luveris) to a regimen of recFSH (Gonal-F) and GnRH antagonist (Cetrotide) improve ovarian response and implantation rates in patients age >35 years undergoing IVF/ET?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON29497

Enrollment

600

Registered

2005-12-13

Start date

2006-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subfertile women undergoing IVF or ICSI, age > 35 years

Interventions

Patients will receive a standard protocol of Gonal-F (follitropine

225IU/day) from cycle day 2-4 and Cetrotide (Cetrorelix

0.25mg/day) from day 6 of stimulation. They will be randomized on day 6 of stimulation to receive either Gonal-F and Luveris (150IU/day) or continue with Gonal-F alone. In both cases, the dose of Gona

Eligibility

Inclusion criteria

Inclusion criteria: Age >35 years undergoing IVF or ICSI for any indication.

Exclusion criteria

Exclusion criteria: Women with PCOS.

Design outcomes

Primary

Measure	Time frame
1. Pregnancy rate/embryo transfer; 2. Implantation rate (hCG measurement 15 days after ovum pick up).	—

Secondary

Measure	Time frame
1. Number of follicles >15mm on day hCG; 2. Number of ova collected.	—

Contacts

Public ContactR. Homburg

VU Univeristy Medical Center, Department of Obstetrics and Gynaecology, Division of Reproductive Medicine, P.O. Box 7057

R.homburg@vumc.nl+31 (0)20 4440070

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)