1. Glycocalyx
Conditions
Interventions
Glycocalyx measurements.
Sponsors
Academisch Ziekenhuis Maastricht
P. Debyelaan 25
6229 HX Maastricht
Postadres: Postbus 5800
6202 AZ Maastricht
Telefoon: 043 - 387 65 43
Fax: 043 - 387 78 78
Eligibility
Inclusion criteria
Inclusion criteria: Cases: Subjects should have premature cardiovascular disease, which will be defined as: 1. cardiac vascular disease; 2. cerebral vascular disease; 3. peripheral vascular disease; before the age of 40 years. Furthermore, all of these subjects must have a positive family history for cardiovascular disease. This will be defined as at least one first degree or two or more second degree family members with cardiovascular disease before the age of 55 for men and before the age of 60 for women. 1. Cardiac disease was defined when a subject has had a premature myocardial infarction as diagnosed as such by a cardiologist in the hospital, or a coronary artery bypass graft (CABG)surgery had occurred or has had coronary abnormalities on cardiac catheterization with or without percutanues transluminal coronary angiography (PTCA); 2. Cerebral disease was defined when a subject has had a young stroke or transient ischemic attack (TIA) as diagnosed as such by a neurologist in the hospital. 3. Peripheral vascular disease was defined when a subject has had peripheral arterial occlusive disease as diagnosed as such by a vascular surgeon or a percutaneous transluminal angiography or bypass surgery had occurred. Controls: Controls will be defined as healthy in case they have: 1. no cardiovascular history, such as no cardiac, cerebrovascular or peripheral artery disease; 2. no complaints of angina, claudication or TIA; 3. no family history for cardiovascular disease; 4. they are between the age of 35 and 55 years old.
Exclusion criteria
Exclusion criteria: Cases: Patients will be excluded if they have a positive history for: 1. hypertension; 2. diabetes mellitus; 3. other disease; and in case of: 4. pregnancy; 5. lactating women; 6. if subjects are below the age of 18 years; 7. if subjects are unable to give informed consent. Controls: Controls will be excluded if they have had a: 1. myocardial infarction; 2. CABG; 3. PTCA; 4. stroke; 5. TIA; 6. peripheral occlusive disease; 7. complaints referring to one of these. They are also excluded if they have a: 8. positive family history for cardiovascular disease; 9. history of diabetes; 10. hypertension; 11. hypercholesterolemia; 12. other disease. Besides subjects will be excluded in case of: 13. pregnancy; 14. lactating women; 15. if subjects are below the age of 18 years; 16. if subjects are unable to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The systemic volume of the intravascular glycocalyx in subjects with premature atherosclerosis versus healthy control subjects. | — |
Contacts
Public ContactS.J. Pinto-Sietsma
AZM, Afdeling Interne Geneeskunde Postbus 5800
Outcome results
None listed