Binge Eating Disorder
Conditions
Interventions
We will compare the response of the brain to a commercially available candy bar (processed) with a mix of peanuts and dried dates (unprocessed) matched for total calories, carbohydrates, fat, and prot
Sponsors
n.a.
Eligibility
Inclusion criteria
Inclusion criteria: Control subjects: • Aged >18 • Female • BMI >18,5 and 18 • Female • A primary diagnosis of BED according to DSM-IV criteria or subthreshold BED (an average of one binge eating episode a week) • BMI >30
Exclusion criteria
Exclusion criteria: • Age 18,5 and <25 for control subjects and BMI <30 for BED patients • Male sex • Diabetes • Any know food allergy or intolerance • Renal or hepatic disease • Use of medication known to affect glucose (for example prednisone) or lipid metabolism • A current history of self-induced vomiting, misuse of laxatives, diuretics, enemas, diet pills or other weight controlling medications, fasting, or excessive exercise within the last 24 weeks; • A comorbid diagnosis of psychotic disorder, self-damaging behaviors or mental deficiency • Pregnancy • Any contra-indication to MRI scanning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Changes in brain connectivity and activity (BOLD signal), Z-scores for functional connectivity, eigen vector values) after ingestion of different food stimuli within groups 2.Differences in brain connectivity and activity (BOLD signa)l, Z-scores for functional connectivity, eigen vector values) after ingestion of different food stimuli between groups | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Visual Analogue Scale (VAS) scores for the level of hunger, thirst and satiety before and after ingestion of the food stimuli. | — |
Contacts
Public ContactAnna Maria van Opstal
Leiden University Medical Center
Outcome results
None listed