None listed
Conditions
Interventions
Minigrafting in two symmetrical vitiligo patches on the trunk or extremties.
Sponsors
none
Eligibility
Inclusion criteria
Inclusion criteria: 1. Consecutive patients, diagnosed with stable vitiligo vulgaris* with symmetrical vitiligo patches. *Vitiligo vulgaris: a few to many widespread depigmented macules over the entire body, with often a symmetrically distribution pattern. Stable means: no expansion of existing lesions or appearance of new lesions during the previous 6 months, absence of Koebner's phenomenon and a positive minigrafting test; 2. Patients, eligible for minigrafting and NB-UVB/excimer therapy; 3. Adult patients: older than 18 years.
Exclusion criteria
Exclusion criteria: Patients: 1. With a history of hypertrophic scarring and/or keloid; 2. History of allergic/phototoxic reaction (Lidocaine, Tegaderm, Suture strips, sunlight); 3. With a negative minigrafting test; 4. With a personal or a family history of skin cancer (non-melanoma skin cancer: first degree family members, melanoma: any family member); 5. With a personal history of photosensitivity and/or phototoxicity disorders; 6. With skin type I (according to Fitzpatrick classification I-VI); 7. Who are pregnant; 8. Who are taking medications known to cause photosensitivity and/or phototoxicity and chronic or very frequent use of any medication that can influence the UVB response (eg. tetracycline, retinoids, sulfonamids, psoralens, NSAID¡¯s); 9. With other skin diseases that would impair evaluation of repigmentation, such as psoriasis and eczema; 10. Who are not able to have 2 times weekly NB-UVB/Excimer therapy; 11. With local immunosuppressive treatment or 6 weeks prior to enrolment. For these patients a washout period of 6 weekswill be required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage, start and grade of repigmentation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient satisfaction. | — |
Contacts
Public ContactM.W. Linthorst Homan
Academic Medical Center (AMC), Department of Dermatology, Netherlands Institute of Pigmentary Disorders Meibergdreef 35
Outcome results
None listed