contrast induced acute kidney injury (CI-AKI)
Conditions
Interventions
Randomisation in a 1:1 ratio to:
1. 1 hour prehydration with 250 ml 1.4% sodium bicarbonate
2. No preventive hydration.
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with an eGFR (estimated glomerular filtration rate 30-45 ml/min); 2. Patients with an eGFR 45-60 ml/min and diabetes mellitus (either type 1 or 2); 3. Patients with an eGFR 45-60 ml/min and at least two of the following: Peripheral artery disease, congestive heart failure, age > 75 years, anemia, contrastvolumes > 150 cc or the use of nephrotoxic medication; 4. Informed consent.
Exclusion criteria
Exclusion criteria: 1. eGFR 20%); 9. Known allergy for iodinated contrast media.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean relative increase in serum creatinine. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of CIN; 2. Recovery of renal function 2 months after CT in patients who developed CIN; 3. Mean relative increase in serum creatinine 7-14 days after contrast administration; 4. Acute kidney injury according to the serum creatinine based RIFLE criteria; 5. The need for dialysis; 6. (Re)hospitalisation, duration of hospitalisation in the two months following randomisation; 7. Visits to the outpatient clinic in the two months following randomisation. | — |
Contacts
Public ContactJudith Kooiman
Leiden University Medical Center, Albinusdreef 2, Postzone C4-70
Outcome results
None listed