Acute gout.
Conditions
Interventions
Five days, by oral administration, either prednisolon 35mg (= 30mg prednisone) once a day or naproxen at a dose of 500 mg twice a day. Patients received blind capsules containing active prednisolon an
Sponsors
No competing interests
Eligibility
Inclusion criteria
Inclusion criteria: All patients referred by their general practitioner because of a mono-arthritis to the rheumatology department of one hospital, who proved to have urate crystals after diagnostic joint aspiration.
Exclusion criteria
Exclusion criteria: 1. Use of anti-trombolytica; 2. A history of peptic ulcera; 3. A history of reduced renal function; 4. A history of heart failure; 5. A known hypersensitivity to naproxen and/or prednisone; 6. Use of any NSAID or prednisone within the past 12 hours; 7. Unwillingness to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient assessment of pain in the study joint, indicated on visual anlogical scales two times a day, during 4 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Patients’ global disability; 2. The walking disability, if the study joint was in the leg or foot; 3. Safety and tolerability of prednisone versus naproxen. | — |
Contacts
Public ContactEloy Lisdonk, van de
University Medical Center St. Radboud, Department of General Practice and Family Medicine, P.O. Box 9191
Outcome results
None listed