obesity insulin sensitivity bariatric surgery hypothalamus obesitas insuline gevoeligheid bariatrische chirurgie hypothalamus
Conditions
Interventions
Bariatric surgery
Sponsors
Academic Medical Center (AMC), Department of Endocrinology and Metabolism
P.O. Box 22660
1100 DD
Amsterdam
The Netherlands
+31 (0)20 5669111
Eligibility
Inclusion criteria
Inclusion criteria: 1. 20 pre-menopausal Caucasian women scheduled for Roux-en-Y gastric bypass surgery 2. Written informed consent
Exclusion criteria
Exclusion criteria: 1. Any chronical medical condition except for glucose intolerance, hypertension and secondary dyslipidemia 2. Use of medication which interferes with dopamine metabolism 3. Clinically overt atherosclerotic events 4. Claustrophobia and no unremovable metal objects 5. Tobacco use (i.e. smokers) 6. Malignant or uncontrolled hypertension (blood pressure >200/120 mmHg or blood pressure >180/110 mmHg with 1 or more drugs, or >160/100 with 2 or more drugs) 7. Unwilling or unable to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - insulin sensitivity - metabolic changes pre- post operative - metabolic differences between two subgroups - changes in hypothalamus pre- post operative - brain differences between two subgroups | — |
Secondary
| Measure | Time frame |
|---|---|
| - weight loss | — |
Contacts
Public ContactB.A.M. Weijer, de
Academic Medical Center (AMC) Department of Endocrinology and Metabolism P.O. Box 22660 1100 DD
Outcome results
None listed