Overeating, obesity, overweight over eaten, obesitas, overgewicht
Conditions
Interventions
This study investigates changes in brain responses as satiation progresses. In order to study this we will measure resting state brain activity and brain reactivity to taste in 1) a hungry state, 2) a
Sponsors
Wageningen University
Eligibility
Inclusion criteria
Inclusion criteria: • Right handed (Left and right handed people show differences in brain activation when tasting) • Between 18-35 years old at the day of inclusion • Able to understand and speak English fluently or without difficulty (self-report) • BMI 18.5-27 kg/m2 • Good general health and appetite (see F1 questionnaire self-report) • Willing to comply with the study procedures • Agrees on being informed about incidental findings of pathology through his general practitioner
Exclusion criteria
Exclusion criteria: • Failing to meet one or more of the inclusion criteria • Women: being pregnant, having the intention to become pregnant within half a year. • Women: using a IUD as anti-conceptive ( with exception of the Mirena IUD which is MRI safe). • Having difficulties with tasting, smelling, swallowing or eating in general. • Suffering from a neurological, endocrine, or eating disorder, gastrointestinal or mental illness or illness of the thyroid gland, respiratory disease or diabetes. • Having sight (except glasses) or hearing disorder (self-report) • Having non-removable dental braces (with the exception of a dental wire) • Smoking: smoking on average one or more cigarettes/cigars a day • Having a history of, or current alcohol consumption of, drinking on average more than 21 units per week (cut-of based on ref (50)) • Not willing to stop using drugs during the study period (from inclusion till test session) • Use of medication that may influence study outcomes (self-report, see F1 questionnaire) • Allergies or intolerance to any ingredient of the test foods. • Not willing to eat the test food/drink because of eating habits or believes. • Followed an energy restricted diet during the last 2 months • Gained or lost 5 kg of body weight over the last half year • High restrained eater according to the Dutch Eating Behaviour Questionnaire • Participating in another research study • Employee of Human Nutrition department of Wageningen university • Thesis student or intern at the chair group of Sensory Science and Eating Behaviour Human Nutrition (WUR). • not having a general practitioner • Intensive exercising more than 8 hours per week • Low score ( 4, neutral) for liking the test food on a nine point likert scale* MRI related exclusion criteria: • Not willing to be in an MRI scanner • Claustrophobic (self-report) • Having a contra-indication to MRI scanning (including, but not limited to): • Pacemakers and defibrillators • Epilepsy or family history of epilepsy • Intraorbital or intraocular metallic fragments • Ferromagnetic implants • Presence of non-removable piercings
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in brain activity in rest and in reactivity (BOLD signal) upon oro-sensory exposure to food, between hungry and progressive satiated states. Regions of interest (ROI) are: •Satiation: Brainstem (dorsal vagal complex (DVC), nucleus tractus solitarius (NTS), parabrachial nucleus (PBN)), Hypothalamus •Taste perception: primary: Insula, overlying operculum, secondary: orbitofrontal cortex, Thalamus •Reward: striatum (nucleus accumbens, Putamen), amygdala, Hippocampus, Midbrain (Ventral tregmental area (VTA), substantia nigra), medial pre frontal cortex. In addition to these ROI we are interested in brain activity networks (functional connectivity). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome is stomach filling (ml) measured by MRI. | — |
Contacts
Public ContactMarlou Lasschuijt
Wageningen University
Outcome results
None listed