Subfertility, IVF, ART, uterine contractions
Conditions
Interventions
Simultaneous measurements with abdominal electrohysterography and transvaginal ultrasound.
Co-interventions:
In Phase IIa, IIIa and IIIb blood tests are performed to assess hormone levels (estradiol,
Sponsors
Catharina Ziekenhuis, Eindhoven
Eligibility
Inclusion criteria
Inclusion criteria: Phase I: - Age 18-40 years - Under hormonal fertility treatment Phase IIa: - Age =18 and premenopausal - Regular, natural menstrual cycle Phase IIb: - Age =18 and premenopausal - Indication for hysterectomy in near future Phase IIIa: - Age 18-40 - Regular, natural menstrual cycle Phase IIIb: - Age 18-40 - Under hormonal fertility treatment
Exclusion criteria
Exclusion criteria: Phase I: - Pregnancy - Mental disability - Significant language barrier - Uterine anomalies (congenital or not congenital) - Uterine pathologies (leiomyomas, adenomyosis, endometriosis) - Caesarean section in the past Phase IIa: - Like in Phase I (Pregnancy, Mental disability, Significant language barrier, Uterine anomalies (congenital or not congenital), Uterine pathologies (leiomyomas, adenomyosis, endometriosis), Caesarean section in the past) - Hormonal medication of any kind Phase IIb: - Like in Phase I Phase IIIa: - Exclusion criteria of Phase II - Known infertility Phase IIIb: - Exclusion criteria of Phase I
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Test reliability of electrohysterographic and automated ultrasound for assessing uterine contractions during different phases of the normal menstrual cycle in a prospective selected cohort. 2. Determine objective changes in electric activity and subsequent endometrial wave patterns in relation to phase of menstrual cycle (characterization of waves). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Identification of prognostic features of electrohysterographic and automated ultrasound for the success rate of fertility treatment. 2. Identifying the role of sex-hormone blood levels in the characteristics of endometrial waves. | — |
Contacts
Public ContactN.P.M. Kuijsters
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Outcome results
None listed