Neurobiological mechanism underlying MDMA-induced prosocial behaviour
Conditions
Interventions
1. MDMA-75 mg
2. Ketanserin-40mg
3. MDMA-75mg + Ketanserin-40 mg
4. Double placebo.
Sponsors
Maastricht University, K. P. C. Kuypers
Eligibility
Inclusion criteria
Inclusion criteria: 1. Experience with the use of MDMA (maximally 200 times in total, minimally 3 times in total; and at least once in the past 12 months): This will be assessed by means of a drug history questionnaire and an interview by the medical supervisor; 2. Age between 18-35 years; 3. Free from medication (except oral contraception); 4. Good physical health as determined by examination and laboratory analysis; 5. Absence of any major medical, endocrine and neurological condition; 6. Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2; 7. Written Informed Consent; 8. Fluent Dutch speaker (as some tasks require this).
Exclusion criteria
Exclusion criteria: 1. History of drug abuse (other than the use of MDMA) or addiction; 2. Current or history of psychiatric disorder; 3. Women: Pregnancy or lactation; 4. Cardiovascular abnormalities as indicated by: A. The medical questionnaire and/or; B. The standard 12-lead ECG. 5. Excessive drinking (> 20 alcoholic consumptions a week); 6. Hypertension (diastolic> 90; systolic> 140).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive and affective empathy. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Social interaction (trust, reciprocity); 2. Implicit attitudes; 3. Processing of affective sounds; 4. Verbal memory. | — |
Contacts
Public ContactK.P.C. Kuypers
P.O. Box 616
Outcome results
None listed