Posttraumatic Stress Disorder (PTSD)
Conditions
Interventions
1. Trauma-focused cognitive behavioural therapy (TF-CBT), consisting of 12 weeksly sessions
2. Paroxetine (Seroxat) treatment lasts for 24 weeks. Treatment will be initiated at 20 mg daily for four weeks and can be increased by increments of 10mg/daily each four weeks up to a maximum of 60 m
Sponsors
Academic Medical Center, University of Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with a diagnosis of chronic PTSD (> 3 months); 2. CAPS score of 45 and higher; 3. Male and female, aged 18 years and above; 4. Written informed consent; 5. Eligible for exposure therapy.
Exclusion criteria
Exclusion criteria: 1. Suicidal risk; 2. Presence of any of the following DSM IV diagnoses: Psychotic disorder incl. schizophrenia, a bipolar disorder, depression with psychotic features, or excessive substance related disorder over the past 6 months; 3. Female patients of childbearing potential must have a negative pregnancy test; 4. Primary diagnosis of severe depressive disorder; 5. Presence of primary or co-morbid personality disorder; 6. An organic disorder; 7. Intolerance to paroxetine or any other SSRI, taking psychotropic medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The change in Clinician Administered PTSD Scale (CAPS) at 1 week, 3 months, 6 months, 12 and 18 months after treatment; 2. (Unit) costs associated with an improved PTSD outcome in terms of CAPS scores at 1 week, 3 months, 6 months and 12 and 18 months after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| At 1 week, and 3, 6, 12 and 18 months post-intervention the following secondary outcomes will be assessed as well: 1. Other psychopathology; 2. Quality of life; 3. Anxiety and depression and costs; 4. Neurocognitive, neuroimmune and genetic measures. | — |
Contacts
Public ContactM. Olff
Meibergdreef 5, PA3-118
Outcome results
None listed