The requirement of the essential amino acids in the Asian and Caucasian newborn. De behoefte van de essentiele aminozuren in de voeding van de pasgeborene.

Essential amino acid requirements of term and preterm Asian and Caucasian neonates determined by the IAAO method.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON29361

Enrollment

300

Registered

2009-01-07

Start date

2008-10-15

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

essential amino acids- neonates- requirements- newborn- protein essentiele aminozuren- neonaten- behoefte- eiwit

Interventions

24 hours adaptation to study formula. On the studyday ( 8 hours): studyformula, an intragastric tube with orally infused tracer ( stable isotope). Sampling by breath sampling at the start of the stu

Eligibility

Inclusion criteria

Inclusion criteria: Term: 1. Gestational age 37-42 weeks; 2. growth > 5 g/kg/d in the last 5 d; 3. birthweight > 2200 g; Preterm: 1. Gestational age 28-37 weeks; 2. growth > 10 g/kg/d in the last 5d; 3. birthweight < 2200.

Exclusion criteria

Exclusion criteria: 1. Gastro-intestinal pathology; 2. sepsis; 3. congenital abnormalities; 4. no informed consent.

Design outcomes

Primary

Measure	Time frame
The requirement of all 9 essential amino acids in preterm and term neonates by determination of a breakpoint (by biphase regression analysis).	—

Secondary

Measure	Time frame
Time needed for adaptation to the study formula. Validation of the breath sampling method by comparing it with blood and urine.	—

Contacts

Public ContactJ.B. Goudoever, van

Erasmus Medical Center, Sophia Children's Hospital P.O. Box 2060

j.vangoudoever@erasmusmc.nl+31 (0)10 4636363

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)