Child
Conditions
Interventions
Patients will be given standard nutrition(elementary diet administered via continuous enteral drip) or total parenteral nutrition during 2 identical chemotherapy courses. Using a crossover design, eac
Sponsors
University Medical Center Groningen (UMCG), Beatrix Children's Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Children(0-18 years of age) admitted to the University Medical Center Groningen for the treatment of acute myeloid leukemia(AML) or B-Non Hodgkin lymphoma(B-NHL). They receive chemotherapy according to the Dutch Childhood Oncology Group(DCOG), for both AML and B-NHL containing at least 2 identical chemotherapy courses.
Exclusion criteria
Exclusion criteria: -Patients and their parents are excluded when they are insufficiently capable of speaking and understanding the Dutch language. -Patients are excluded when life expectancy is estimated to be below six months. -No gastric tube in place in children who do eat during their chemotherapy (very rare) are excluded since we do not give a naso-gastric tube only for study purposes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Nutritional state (weight, length, mid upper arm circumference) | — |
Secondary
| Measure | Time frame |
|---|---|
| - The degree of mucositis measured by plasma citrulline - Quality of life (using Pedsqual questionnaire every 5 days and daily Cantrills ladder and VAS score) - Number of infectious complications - Number of bacteraemias - Percentage of calculated optimal quantity of tube feeding actually given - Liver toxicity scores according to NCI-CTCAE version 4.0 - Length of hospital stay - Clinical symptoms of mucositis (NCI-CTCAE 4.0) | — |
Contacts
Public ContactW.J.E. Tissing
Posbus 30 001
Outcome results
None listed