The effects of intranasal insulin on glucose metabolism in healthy men.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON29342

Enrollment

Registered

2009-09-09

Start date

2009-01-10

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus type II (DM II) glucose metabolism/glucose metabolisme

Interventions

Each subject will be studied twice. Intranasal insulin and placebo will be administered. Glucose metabolism will be measured using stable isotopes. An intraspinal catheter will be inserted during the

Eligibility

Inclusion criteria

Inclusion criteria: 1. Lean healthy male volunteers; 2. Age 18-35 years; 3. BMI 20-25 kg/m2; 4. Normal oral glucose intolerance test according to the ADA-criteria.

Exclusion criteria

Exclusion criteria: 1. Any medication or substance use; 2. DM II; 3. Smoking; 4. Alcohol abuse (>3/day); 5. Lipid disorders, renal insufficiency, elevated liver enzymes or TSH; 6. Bleeding disorders; 7. Prior surgery of the nose and/or septum; 8. Allergic rhinitis; 9. Known allergies to antibiotics, used as prophylaxis in this study.

Design outcomes

Primary

Measure	Time frame
Endogenous glocose production.	—

Secondary

Measure	Time frame
Insulin concentration in the CSF.	—

Contacts

Public ContactN.M. Lammers

Academic Medical Centre (AMC) Department of Endocrinology & Metabolism F5-162

N.M.Lammers@amc.uva.nl+31 (0)20 5662663

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)