microcirculation
Conditions
Interventions
Healthy volunteers:
Subjects are first exposed to a bolus of crystalloid fluid (300 ml), which is followed by a bolus of colloid fluid (gelofusine) (300 ml).
Before and after fluid administration, the
Sponsors
VU University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Healthy volunteers (n=19): Age 18-85 years, normal renal function, normal liver function Patients (n=26) undergoing elective abdominal surgery under general anesthesia, age 18-85 years, normal renal function, normal liver function
Exclusion criteria
Exclusion criteria: Healthy volunteers: Peripheral edema Cardiovascular disease (hypertension, myocardial ischemia, heart failure) Allergy to gelatines Use of antihypertensive, diuretics Severe asthma Patients: Peripheral edema Myocardial infarction, heart failure, renal replacement therapy Use of diuretics Previous chemotherapy Diabetes mellitus I or II with use of anti-diabetic medication User of steroids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microcirculatory perfused vessel density (PVD) and perfused boundary region (PBR) measured using sublingual Capiscope imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative administered fluid volume, fluid balance, urine output Microvascular Flow Index (MFI) Microvascular flow heterogeneity Hemodynamic parameters (blood pressure, heart frequency, pulse pressure variation in mechanically ventilated patients, stroke volume, cardiac index). | — |
Contacts
Public ContactChrista Boer
VU University Medical Center, Department of Anesthesiology
Outcome results
None listed