High altitude Physical exercise Blood coagulation Thrombosis Extreme hoogte Lichamelijke ispanning Bloedstolling Trombose
Conditions
Interventions
- Strenuous physical exercise (heart rate reserve 60-85%) during 2 hours, once at sea level (baseline) and repeated 3x at high altitude (3,883 m above sea level)
- Venipuncture just before and immedi
Sponsors
Maastricht University Medical Center
Synapse Research Institute
Eligibility
Inclusion criteria
Inclusion criteria: - Healthy male volunteer - Age between 18 and 50 years old
Exclusion criteria
Exclusion criteria: - Previous history of cardiovascular disease, pulmonary disease, bleeding disorder or venous thromboembolism - Medication interfering with blood coagulation (low molecular weight heparins, vitamin K antagonists, direct oral anticoagulants, non-steroidal anti-inflammatory drugs) - Impaired mobility - Active smoking - Not passing medical assessment - Disapproval of contacting general practitioner in case of abnormalities found during medical assessment or during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Trombin generation | — |
Secondary
| Measure | Time frame |
|---|---|
| - Plasmin generation - Platelet function test - Thromboelastometry - Blood count - Fibrinolysis (clot lysis time) - Coagulation factor analysis: von Willebrand factor (vWF), factor 8 (FVIII), D-dimers - Biochemical markers: lactate, creatinine, urea, albumin Other outcome parameters: - Age - Vital signs (heart rate, blood pressure and SpO2) - Questionnaire (Lake Louise AMS) | — |
Contacts
Public ContactC.H. Kicken
Maastricht University Medical Center, department of Anesthesiology and Pain Therapy;
Outcome results
None listed