EN: glioma NL: glioom
Conditions
Interventions
Observational study with PET and MRI previous to stereotactic biopsies in and around the tumor.
Sponsors
VU University medical center
Eligibility
Inclusion criteria
Inclusion criteria: Patients of 18 years and older with a MRI interpretation by an expert neuroradiologist of a diffuse infiltrative glioma, and who have an indication, confirmed by the multidisciplinary neuro-oncology tumor-board, for resective surgery.
Exclusion criteria
Exclusion criteria: Patients who are pregnant or underwent previous brain surgery, cranial irradiation or chemotherapy. Patients with other brain pathology on MRI, such as stroke or multiple sclerosis. Patients with a tumor located infratentorially or in the spinal cord. Withdrawal criteria Patients who do not successfully undergo one PET scan in phase I and III or both PET scans in phase II.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Qualitative (high, normal or low signal) and quantitative parameters of MRI and PET for each biopsy site - Qualitative (central glioma, glioma infiltration, normal brain or uninformative) histopathological score of each biopsy site | — |
Secondary
| Measure | Time frame |
|---|---|
| - Gene expression of each biopsy site | — |
Contacts
Public ContactP.C. de Witt Hamer
Department of Neurosurgery - VU University Medical Center (VUmc)
Outcome results
None listed