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Effect of lowering the transition metals and ammonium concentration in human culture media on the quality of the human embryos.

Removal of transition metals and ammonium from human IVF culture system.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON29264
Enrollment
100
Registered
2008-12-12
Start date
2009-02-01
Completion date
Unknown
Last updated
2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

In vitro fertilisation, human embryo, embryo culture, ammonium, transition metals

Interventions

Embryo culture will be performed with or without the inorganic ionexchanger Tramm-ex. The randomisation is performed by ‘the research randomizer’ on 100 consecutive patients undergoing IVF/ICSI treatm

Sponsors

GIFT, ZOL, Genk, Belgium Private infertility center in a university-affiliated teaching hospital and Newcastle Fertility Centre at LIFE, Newcastle, UK, University affiliated Center. M. Nijs, GIFT, Genk and Herbert M, LIFE, Newcastle.
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients entering the IVF/ICSI program.

Exclusion criteria

Exclusion criteria: 1. ICSI cases for preimplantation genetic diagnosis; 2. ICSI cases with testicular spermatozoa.

Design outcomes

Secondary

MeasureTime frame
1. Metabolomic profiling of embryo culture medium; 2. delivery rate; 3. health of baby.—

Primary

MeasureTime frame
Embryo quality (quality and cell number in embryo) and clinical pregnancy rate.—

Contacts

Public ContactM. Nijs

Schiepse Bos 6

martine.nijs@zol.be

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)