Unruptured intracranial aneurysm
Conditions
Interventions
18F-IL2 PET-CTA
Sponsors
UMC Groningen
Eligibility
Inclusion criteria
Inclusion criteria: - Age > 18 year - Presence of an unruptured intracranial aneurysm - Standard of care decision to treat the aneurysm - The aneurysm is surgically accessible - Aneurysm wall sampling is deemed possible by the surgeon - Written informed consent
Exclusion criteria
Exclusion criteria: - Prior therapy on the targeted unruptured intracranial aneurysm - Presence of intracranial neurovascular disorders, other than intracranial aneurysms - Contra-indications to general anesthesia or craniotomy o Thrombocytopenia (1.5) - Contra-indications to 18F-IL2 PET-CTA o Technical impairments to perform the study  Incapacity to lie still for 30 minutes  Physical restrictions, e.g. morbid obesity  Claustrophobia o Pregnancy or lactation o Renal insufficiency (estimated glomerular filtration rate < 60 ml/min/1.73 m2) o Known allergy to iodine contrast agent o Treatment with metformine o Morbus Kahler / M. Waldenstrom o Myasthenia gravis o Pheochromocytoma o Mastocytosis o Thyroid cancer o Planned thyroid scan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prediction of inflammation by 18F-IL2 PET-CTA, related to the gold standard of histopathological examination (proof-of-concept). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blinded analysis of interobserver variability in 18F-IL2 PET-CTA interpretation. | — |
Contacts
Public ContactJ.M.C. van Dijk
UMC Groningen
Outcome results
None listed