Preoperative predictors of weight loss and improved metabolic health after bariatric surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON29250

Enrollment

1299

Registered

2021-04-28

Start date

2021-07-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: ? Ability to provide informed consent ? Patient is = 18 and = 75 years old ? BMI = 40 kg/m2 or = 35 kg/m2 with obesity related comorbidity ? Scheduled for primary bariatric procedure: Roux-en-Y gastric bypass or Sleeve Gastrectomy ? Stable weight 3 months prior to inclusion weight (<10% change in body weight for 3 months prior to assessments)

Exclusion criteria

Exclusion criteria: ? Patients who do not understand the patient information letter ? Coagulation disorders ? Type 1 diabetes ? Severe liver disease ? Renal dysfunction ? Pregnancy anticipated in the first two years following surgery ? Use of antibiotics in last 6 months prior to inclusion ? Use of probiotics in last 6 months prior to inclusion

Design outcomes

Primary

Measure	Time frame
To validate biomarkers of response to bariatric surgery and to develop algorithms, which combine these variables, to predict individual responses.	—

Secondary

Measure	Time frame
- To determine if psychological factors (depression, anxiety, binge eating, eating behavior, food craving, body image, compliance to follow-up) are associated with genetic predisposition and to study how these psychological factors are associated with weight loss, metabolic health and improvement of QoL after bariatric surgery; - To study the difference in cardiorespiratory fitness, muscle strength and physical activity and the relationship of these measurements with weight loss, metabolic health and QoL after bariatric surgery; - To establish predictive (bio)markers of long-term outcomes after bariatric surgery (5-year follow-up). In a subgroup of 40 patients, we have additional secondary objectives: - To examine the change of gut hormones and inflammatory markers between 0-3 months after surgery and to evaluate the predictive value of these changes for weight loss and metabolic health 12 months after surgery.	—

Measure

Time frame

- To determine if psychological factors (depression, anxiety, binge eating, eating behavior, food craving, body image, compliance to follow-up) are associated with genetic predisposition and to study how these psychological factors are associated with weight loss, metabolic health and improvement of QoL after bariatric surgery; - To study the difference in cardiorespiratory fitness, muscle strength and physical activity and the relationship of these measurements with weight loss, metabolic health and QoL after bariatric surgery; - To establish predictive (bio)markers of long-term outcomes after bariatric surgery (5-year follow-up). In a subgroup of 40 patients, we have additional secondary objectives: - To examine the change of gut hormones and inflammatory markers between 0-3 months after surgery and to evaluate the predictive value of these changes for weight loss and metabolic health 12 months after surgery.

—

Contacts

Public ContactRieneke van der Meer

Amsterdam Universitair Medische Centra

r.vandermeer1@amsterdamumc.nl+31 653148089

Outcome results