Diabetes, insulin resistance, hyperglycemia.
Conditions
Interventions
Acute submaximal exercise bouts in hypoxic and hyperoxic conditions.
Sponsors
Erasmus University
Eligibility
Inclusion criteria
Inclusion criteria: 1. DM2 >3 months; 2. Age: 40-65 years; 3. BMI between 27 and 35 kg/m2; 4. Formal permission to participate in the study by signing an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Cardiovascular disease: Objective heart failure (ejection fraction <35%), electrocardiographically diagnosed cardiac ischemia or symptomatic peripheral vascular disease diagnosed by Doppler ultrasound investigation; 2. Serious orthopedic of neurological conditions precluding an exercise test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of the 24-hour glycemic profile in response to acute sub-maximal hypoxic and hyperoxic exercise in order to determine its effectiveness and select the most efficient method in reducing post-exercise hyperglycemia prevalence in comparison with normoxic conditions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison and selection of oxygen conditions which amplify stimulation of muscle blood flow/ improve exercise tolerance during exertion. Moreover, obtained peripheral and central hemodynamic/respiratory responses will demonstrate the net result of acute exercise in various oxygen conditions. The latter will contribute to optimize exercise therapy in DM2 patients with impaired exercise tolerance and diabetes complications. | — |
Contacts
Public ContactRobert Mankowski
Erasmus MC Department of Rehabilitation Medicine and Physiotherapy Mailbox 2040
Outcome results
None listed