ECLS, ECMO, adults, coagulation
Conditions
Interventions
Collecting data about coagulation tests during ECLS, including conventional tests such as APTT, PT, platelets, D-dimer, free Hb and alternative tests, including LORCA and Multiplate
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: All adult patients who start with ECLS in the ICU (according to the guidelines, ECLS can be considered in acute severe heart or lung failure with high mortality risk despite optimal conventional therapy).
Exclusion criteria
Exclusion criteria: - Pregnancy - Start of ECLS not in the ICU, e.g. after cardiothoracic surgery - Use of ECLS only for high risk procedure like percutaneous cardiac intervention with planned removal of ECLS within 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Red blood cell aggregation and elongation (deformability) assessed by a laser assisted optical rotational cell analyzer (LORCA) on days 1-3, and within 24 hours after weaning of ECLS | — |
Secondary
| Measure | Time frame |
|---|---|
| Red blood cell aggregation and elongation (deformability) assessed by a LORCA on 5, 7, 10, 14, 21 (when appropriate) and within 24 hours after weaning of ECLS. Platelet aggregation assessed by the multiple platelet function analyzer (Multiplate) on days 1, 2, 3, 5, 7, 10, 14, 21 (when appropriate) and within 24 hours after weaning of ECLS. Aditional coagulation parameters on days 1, 2, 3, 5, 7, 10, 14, 21 (when appropriate) and within 24 hours after weaning of ECLS. | — |
Contacts
Public ContactA. Oude Lansink
afdeling Intensive Care Volwassenen
Outcome results
None listed