None listed
Conditions
Interventions
Participants will be presented two sessions (placebo/nicotine, sessions are separated by at least a week). In each session, before and after nicotine or placebo intake, participants will be assessed w
Sponsors
Utrecht University
Eligibility
Inclusion criteria
Inclusion criteria: Participants must be male and between 18-40 years old.
Exclusion criteria
Exclusion criteria: 1. Hypersensitivity to nicotine or other substances in the chewing-gum; 2. Oral infection or pharyngitis; 3. Active oesophagitis; 4. (History of) cardiovascular disease; 5. Liver failure / insufficiency; 6. Kidney failure / insufficiency; 7. Diabetes mellitus; 8. Use of medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Independent variable: Cholinergic agonism. In the Visual Spatial Cueing (VSC) paradigm the dependant variables are: 1. The validity effect in ms, specifically, reaction time validly cued targets minus reaction time invalidly cued targets (Both bias and disengagement related); 2. Parietal cue ERP components (EDAN + LDAP ERP components) (Bias related); 3. P1 validly cued target ERP (Bias related); 4. LPD invalidly cued target ERP (Disengagement related). In the stop task paradigm the dependant variables are: 1. Stop signal reaction time (SSRT) in ms (both bias and disengagement related); 2. N2 stop signal ERP (Disengagement related); 3. LPD stop signal ERP (Disengagement related). It is expected that facilitated cholinergic neurotransmission by nicotine will result in increased disengagement but will not affect bias. | — |
Secondary
| Measure | Time frame |
|---|---|
| Independent (subject) variable: Smoking. Dependent variables are the same as listed above. After placebo, nicotine abstinent smokers will have reduced disengagement (as reflected in EEG and behavioural measures) as compared to healthy subjects. No difference is expected with regard to bias. | — |
Contacts
Public ContactH.N.A. Logemann
Outcome results
None listed