Tremor in Dystonia and Essential tremor.

The cerebral mechanisms underlying dystonic and essential tremor: a multimodal network approach

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON29165

Enrollment

Registered

2017-11-30

Start date

2017-12-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

English: Dystonic tremor, Dystonia, Essential tremor, tacs Dutch: Tremor bij Dystonie, Dystonie, Essentiële tremor, tacs, beven

Interventions

Transcranial alternating current stimulation (tacs) over primary motor cortex and cerebellum at tremor frequency and phase locked to ongoing tremor (as measured with accelerometry). Stimulation durin

Eligibility

Inclusion criteria

Inclusion criteria: Essential tremor: -Clinical diagnosis of essential tremor -Postural tremor of both hands -Onset of tremor before the age of 65 Dystonic tremor: -Clinical diagnosis of dystonic tremor -Primary focal / segmental dystonia -Presence of postural tremor of at least one arm (which may or may not be the dystonic limb)

Exclusion criteria

Exclusion criteria: -Neurological co-morbidity -Moderate to severe head tremor (to avoid artifacts caused by extensive head motion during scanning) -Cognitive dysfunction (clinical diagnosis of mild cognitive impairment or dementia) -Considerable diagnostic doubt between essential and dystonic tremor (no consensus reached in team meetings neurologists or considerable doubt in medical record). -Use of anti-tremor medication other than propranolol -Any contraindications for MRI or transcranial stimulation (e.g. non compatible metal implants, epilepsy, active implants).

Design outcomes

Primary

Measure	Time frame
1) phase specific tremor power suppression during M1 tacs, in ET vs DT 2) phase specific tremor power suppression during Cerebellar tacs, in ET vs DT 3) Phase specific tremor related cerebral activity during cerebellar tacs, in ET vs DT	—

Secondary

Measure	Time frame
-Tremor related cerebral activity and connectivity, compared between dystonic and essential tremor. -GABA concentrations in GPi, cerebellum and primary motor cortex, compared between dystonic and essential tremor.	—

Contacts

Public ContactFreek Nieuwhof

freek.nieuwhof@radboudumc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)