cystic fibrosis, microbiomics, resistomics, pathogens
Conditions
Interventions
In both groups of children (CF and healthy) transnasal nasopharyngeal swabs and saliva and feces samples will be collected.
Sponsors
University Medical Center Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of cystic fibrosis; 2. Age < 3 months at time of inclusion.
Exclusion criteria
Exclusion criteria: Other underlying disease or prematurity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect that in-depth knowledge about nasopharyngeal colonization profiles of newborns with CF and healthy controls will provide us with new and essential information for unravelling the pathogenic pathway by which upper respiratory bacteria might cause lower respiratory tract pathology in this patient group. In addition we feel that detailed studies of the development of resistance in pathogens in relation to evolution of the human resistome will help us in the future to design tailored antibiotic regimes to prevent resistance development in the respiratoiry pathogens. | — |
Secondary
| Measure | Time frame |
|---|---|
| We will collect saliva samples to investigate the mucosal immune response in relation to natural boosting by pneumococcal colonization and childhood vaccinations in children with CF compared to controls. | — |
Contacts
Public ContactS.M.P.J. Prevaes
WKZ Utrecht, KE 04.133.1 Postbus 85090
Outcome results
None listed