Multiple Sclerosis
Conditions
Interventions
Progressive Resistance Training and High Intensity Interval training
Sponsors
Amsterdam UMC, location VUmc
Eligibility
Inclusion criteria
Inclusion criteria: PMS diagnosis defined as: ‘definite diagnosis of MS according to the 2017 McDonald Criteria with gradual progression of neurological impairments according to the Lublin criteria 2013.’ EDSS Scale 3.5 – 6 Able to participate in the exercise programs, i.e. no contra-indications for training according to the guidelines of the American college of Sports Medicine. o No history of heart problems o No symptoms that might indicate heart problems o No other major health issues Age between 18 and 60 years old Able to understand therapists instructions Fulfilling the safety criteria for magnetic resonance (MR) assessment o No metal inside the body o Not claustrophobic o No pregnancy
Exclusion criteria
Exclusion criteria: Diagnosed with PPMS Relapse within 3 months of baseline visit Severe comorbidity (Cumulative Illness Rating Scale (CIRS) = 3 on 1 or more organ systems). Initiation of Fampridine within 6 months of baseline visit. Depression, Hospital Anxiety and Depression Scale (HADS) score, depression subscale =11 (i.e. indicative of clinical anxiety disorder or clinical depression) Other neurological- and/or musculoskeletal disorders Already participating in a (guided) high intensity exercise training Participating in another intervention study Pregnancy, given birth previous 6 months, or active pregnancy wish.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage brain volume change, a measure of brain atrophy to determine neurodegeneration | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurodegeneration: - White matter microstructural integrity - lesion load - regional atrophy - functional connectivity - Brain derived neurotrophic factors - Serum neurofilament light - Immune cell profiles Disability: - Expanded disability status scale - Cardiorespiratory fitness (VO2peak) - Muscle strength (1-RM) - Cognition (Brief Cognitive Assessment for Multiple Sclerosis) - 25 foot timed walked test - Energy cost of walking - Balance (Berg Balance Scale) - Depression (Hospital Anxiety and Depression Scale) - Disease impact (Multiple Sclerosis Impact Scale) - Fatigue (Checklist Individual Strength) - Health related quality of life (SF-36) - Walking ability (Multiple Sclerosis Walking Scale) - Exercise self-efficacy (Exercise Self-Efficacy Scale) - Stress resilience (Connor Davison Resilience Scale) Cardiovascular risk profile - Anthropometrics (height, weight, % body fat) - Blood pressure - Cardiovascular risk profile in blood (lipid-profiles, CRP, Glucose (HbA1c)) | — |
Contacts
Public ContactArianne Gravesteijn
Amsterdam UMC, location VUmc
Outcome results
None listed