acute childhood asthma
Conditions
Interventions
One dose of 5 mg DNase OR one dose of 5 mg placebo in addition to standard care.
Sponsors
Erasmus MC, Sophia Children's Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Children, aged 2-18 years, with acute asthma who require at least two doses of bronchodilators at the emergency department.
Exclusion criteria
Exclusion criteria: 1. Dyspnoea due to other causes than asthma; 2. Patients with a concurrent chronic pulmonary disease, such as CF, BPD; 3. Patients with a symptomatic cardial or neuromuscular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in asthma score 1 hour after intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Need for hospital admission; 2. Duration of hosptial admission; 3. Asthma score at 2,6,12 and 24 hours after intervention; 4. Heart rate, respiratory rate and oxygen saturation; 5. Need for additional oxygen; 6. Number of bronchodilators; 7. Doctor’s visit or readmission and use of rescue bronchodilator aerosol therapy following 72 hours after discharge from EMD; 8. Cost-consequence analysis. | — |
Contacts
Public ContactR. Boogaard
Erasmus Medical Center, Sophia Children’s Hospital, Department of Pediatric Pulmonology, SB-2666, P.O. Box 2060
Outcome results
None listed