insulin resistance - insuline resistentie diabetes - diabetes mitochondrial function - mitochondiele functie oxidative capacity - oxidatieve capaciteit
Conditions
Interventions
12 healthy subjects wiil undergo in random order a 60h fast (calorie-free drinks only (S)) or a control diet (50-35-15% of energy as CHO, fat and protein (FED)). During the study, subjects stayed in a
Sponsors
Nutrition and Toxicology research Institute Maastricht (NUTRIM)
Maastricht University
PO Box 616, 6200 MD Maastricht
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male sex; 2. Age 18-35 years; 3. BMI <25 kg/m2; 4. Sedentary; 5. Stable dietary habits; 6. Healthy; 7. No (first or second-degree) family member with diagnosed type 2 diabetes.
Exclusion criteria
Exclusion criteria: 1. Female sex; 2. Unstable body weight (weight gain or loss > 3 kg in the past three months); 3. Participation in a regular exercise training program during the last year before the start of the study; 4. Any medical condition requiring treatment and/or medication use; 5. Abuse of drugs and/or alcohol; 6. Participation in another biomedical study within 1 month before the first screening visit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome parameters are skeletal muscle lipid accumulation and insulin sensitivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are mitochondrial damage/oxidative capacity, Substrate oxidation en Energy expenditure | — |
Contacts
Public ContactPatrick Schrauwen
Postbus 616 Department of Human Biology Maastricht University Medical Center
Outcome results
None listed