Rheumatoid Arthritis
Conditions
Interventions
TNF-alpha blockade.
(patients are their own control)
Sponsors
Academic Medical Center
Amsterdam, the Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male or female patients who were priorly diagnosed with RA, who are currently experiencing an inflammatory episode and who will be treated with TNF-alpha blockade; 2. Age 18-80 years.
Exclusion criteria
Exclusion criteria: 1. Patients who were priorly diagnosed with diabetes, hypertension or cardiovascular disease; 2. Current signs or symptoms of severe, progressive or uncontrolled hepatic, haematological, gastroenterological, endocrine, pulmonary, cardiac or neurological disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Endothelial Function (FMD); 2. Glycocalyx; Before treatment, 0-4 weeks after treatment, 9-12 weeks after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Atherosclerosis: Plasma: Total cholesterol, LDL, HDL, Triglycerides, Lp(a), ox-LDL; 2. Thrombosis: D-dimer, F1+2, sTF, PAI-I; 3. Inflammation: IL-1beta, TNF-alpha, IL-6, IL-8, IL-10, hsCRP. Before treatment, 0-4 weeks after treatment, 9-12 weeks after treatment. | — |
Contacts
Public ContactSander Leuven, van
Academic Medical Center (AMC), Department of Vascular Medicine, room F4-159.2, P.O. Box 22660
Outcome results
None listed