fatigue, prophylactic cranial irradiation, small cell lung cancer, MRI vermoeidheid, profylactische schedelbestraling, kleincellig longcarcinoom, MRI
Conditions
Interventions
MRI will be performed approximately one week before PCI and two weeks after PCI. Blood samples will be drawn on the same day as the MRI. Fatigue and quality of life will be measured with questionnair
Sponsors
AzM
PO Box 5800 6202 AZ Maastricht
The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: Stage I-III SCLC: - Age >/= 18 years - stage I-III SCLC pathology proven - Completed initial treatment with chemoradiotherapy, with at least stable disease (SD) - WHO PS 18 years - stage I-III NSCLC pathology proven - Completed treatment with chemoradiotherapy, with at least SD - WHO PS 18 years - WHO PS < 2 - Ability to understand written questionnaires - Written informed consent
Exclusion criteria
Exclusion criteria: - Prior radiotherapy to the brain - Claustrophobia - Pregnancy - Metal implants or other contraindication for MRI - Inability to lie supine for 30 minutes time (MRI) - Antidepressants or steroids for the last two weeks - Clinically relevant anemia (defined as Hb < 5.5 mmol/l) - Chronic renal failure (defined as MDRD-eGFR < 30 ml/min/1.73m) - Liver biochemistry abnormalities (defined as more than two times upper limit of normal) - Major psychiatric illness requiring intervention in secondary care
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in white matter integrity and bold response after PCI. Differences between SCLC patients and controls for change in white matter integrity and bold response. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Relationship between changes in MRI parameters and changes in MVI-20, EORTC c30, EuroQol-5D , HADS and CFQ - Relationship between changes in MRI parameters and changes in IL-6, TNF¦Á, CRP and leukocytes/differential - To evaluate whether there are differences on MRI findings/laboratory findings / questionnaires between SCLC patients treated with PCI, NSCLC patients and healthy controls | — |
Contacts
Public ContactL. Hendriks
Dept of Pulmonary Diseases, MUMC+ PO Box 5800
Outcome results
None listed