Uncomplicated Malaria, Plasmodium falciparum infection.
Conditions
Interventions
Two groups of 75 children meeting the inclusion critera will be enroled to the study and randomized to a treatment with either Lumifantrine and Athemeter or Dihydroartemisinin with Piperaquine. A fing
Sponsors
Royal Tropical Institute Amsterdam, Bio-Medical Research, The Netherlands
Academic Medical Centre, Devision for Tropical Medicine and AIDS, The Netherlands
Sigma Tau, Italy
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age six to 12 years; 2. Resident in research area and able to comlete follow up; 3. Temperature higher than 37.5 degrees but lower than 39.5 degrees or history of fever in last 24 hours; 4. Understanding the procedures of the study by parents or guardian (informed consent); 5. Diagnosed with uncomplicated malaria. P. falciparum only; 6. Parasitaemia 100-100.000 parasites/ul
Exclusion criteria
Exclusion criteria: 1. General danger signs, severe malaria or severe anaemia; 2. Severe malnutrition; 3. Presence of diseases other than malaria causing febrile conditions; 4. Unwilling to participate and sign informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cured from P. falciparum infection with addequate clinical and parasitological respone as defined by WHO guidlines for clinical trails in malaria research. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Difference in cure rate between the different treatments; 2. Effect on transmission stages (gametocytes) of the parasite. | — |
Contacts
Public ContactP. Mens
Royal Tropical Institute
Outcome results
None listed