Disorders related to disturbed dopaminergic functioning.
Conditions
Interventions
This study will have a cross-over design. Twenty healthy male volunteers (mainly students) will be tested after placebo and after 40 mg of methylphenidate (order of treatment will be randomized). Meth
Sponsors
Maastircht University
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy, right handed, male, between 23 and 35 years of age; 2. No history of mental illness or neurological disorders; 3. No history of drug abuse or alcohol abuse; 4. No use of medication.
Exclusion criteria
Exclusion criteria: 1. MRI contra-indications, such as claustrophobia and metal parts in the body; 2. Cardiovascular abnormalities as assessed by standard 12-lead electrocardiogram (ECG); 3. Excessive drinking; 4. Recreational drug use; 5. Hypertension; 6. Contraindications to methylphenidate (as defined in the methylphenidate SmPC).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Regional cerebral blood flow (method: arterial spin labeling MRI) during resting state in the cortex, sub cortical and brain stem regions; 2. Regional blood oxygenated level dependent (BOLD) response (method: BOLD functional MRI) during resting state and during task performance, in the cortex, sub cortical and brain stem regions; 3) Task performance: the number of correct response and the reaction time. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The levels of Ritalinic acid in the blood; 2. Mood and physical complaints (method: questionnaire); 3. Hart and breathing rate (assessed during the scan session). | — |
Contacts
Public ContactLisbeth Evers
Universiteitssingel 40
Outcome results
None listed