SDD, SOD, ICU, antibiotic resistance, selective decontamination
Conditions
Interventions
SDD consists of an oropharyngeal application (every 6 h) of a paste containing colistine, tobramycin and amphotericin B each in a 2% concentration, and administration (every 6 h) of a 10 ml suspension
Sponsors
University Medical Center Utrecht,
Heidelberglaan 100, 3584 CX, Utrecht
phone +31 (0)887555555
Eligibility
Inclusion criteria
Inclusion criteria: Patients admitted to ICU with an expected length of ICU stay of 48 hours.
Exclusion criteria
Exclusion criteria: Patients younger than 18 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Point prevalence of rectal and respiratory colonization with specificantly defined resistant bacteria (both Gram positive and Gram negative) according to the WIP-guidelines. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. ICU-admission until 48 hours after ICU-discharge, and microbiologically documented; 2. Rate of ICU-acquired bacteraemia caused by antibiotic resistant bacteria, expressed as the rate per 100 ICU-acquired bacteraemia caused by all pathogens; 3. Mortality; at day 28, ICU- and in-hospital mortality; 4. Length of ICU-stay; 5. Predefined subgroup analysis: mortality (28 days-, IC- and in-hospital mortality) in two subgroups: surgical and non-surgical patients; 6. Annual use of antibiotics based on pharmacy records. | — |
Contacts
Public ContactE. Oostdijk
University Medical Center Utrecht, Department of Medical Microbiology, Postal address G.04.5.17
Outcome results
None listed