Exploratory measurement of the physiological effects, induced through changes in afterload, of left ventricular strain-volume loop

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28914

Enrollment

Registered

2017-04-18

Start date

2017-04-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None, we will test healthy control subjects

Interventions

To induce the changes in afterload we will use two different interventions: To reduce the afterload (and preload) we will use vasodilative medication (vasodilator&#894

nitroglycerine), which will primary reduce the peripheral vascular resistance. To increase the afterload we will use anti gravity jeans to occlude the blood supply of the legs for 2 minutes (transient

Eligibility

Inclusion criteria

Inclusion criteria: - Age between 18 and 30 or above 60 - Male gender - Mentally competent

Exclusion criteria

Exclusion criteria: - History of cardiovascular diseases - Diabetes Mellitus - Use of medication or other substances which influences the cardiovascular system - Contraindications for the usage of sublingual nitroglycerin

Design outcomes

Primary

Measure	Time frame
The primary study parameter will be the slope of the systolic strain-volume relation (Sslope)	—

Secondary

Measure	Time frame
The secondary parameters will be the early systolic strain (ԑ_ES), peak strain (peak ԑ) and the dissociation between the systolic and diastolic strain-volume relation during early diastole (UNCOUP_ED) and late diastole (UNCOUP_LD).	—

Contacts

Public ContactHugo Hulshof

Phililps van Leijdenlaan 15

Hugo.G.Hulshof@radboudumc.nltelephone +31 (024) 3614209

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)