Catabolic state induced by severe diseases
Conditions
Interventions
Duration of intervention: 28 days
Intervention group: High protein tube feed
Control group: Isocaloric control tube feed
Sponsors
Nutricia Research B.V.
Uppsalalaan 12,
3584 CT Utrecht - The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: - 18 years and over - Male and female - Patient: ICU stay and indication for tube feed via nasogastric tube - BMI > 25.0 kg/m2
Exclusion criteria
Exclusion criteria: - Requiring other specific tube feed for medical reason. - Having any contra-indication to receive tube feed such as severe shock, presence of partial or complete mechanical bowel obstruction, or intestinal ischemia or infarction. - Abnormalities in GI tract which may impact GI function, such as short bowel syndrome - defined as entire length of small bowel totalling 122 centimetres or less-, Ulcerative Colitis or Crohn’s disease or any form of enterostomy - GI tract, abdominal or bariatric surgery within 72 hours before start intake study product or expected in the next 5 days after start study product intake - History of chronic pancreatitis or acute pancreatitis - Expected to need parenteral feeding - Expected to need protein supplementation other than study product - SOFA score >12 from admission to the ICU until 24 hours after admission or until randomisation in case of randomisation before 24 hours after admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| protein intake (g/kg BW/day) | — |
Secondary
| Measure | Time frame |
|---|---|
| gastro intestinal tolerance, energy intake and safety | — |
Contacts
Public ContactGerben Hofman
Outcome results
None listed