Inflammatory bowel disease Pregnancy Gut microbiome
Conditions
Interventions
No interventions
4 visits (1 before pregnancy, and 1 in each trimester) to obtain blood samples, fecal samples and questionnaires
Sponsors
Erasmus Universit Medical Centre Rotterdam
Eligibility
Inclusion criteria
Inclusion criteria: - Female - Age 18-43 - Confirmed diagnosis of CD, UC or IBDu, by endoscopy and/or pathology - Pregnancy wish
Exclusion criteria
Exclusion criteria: - Incapacity to understand pre-conceptional counseling, informed consent and/or questionnaire (e.g. language barrier, no interpreter) - Diabetes mellitus - Infection with HIV, HBV or HCV - Substance abuse (chronic hard drug use, alcoholism, shorter than 2 years clean) - Other auto-immune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - to analyze the gut microbiome of IBD patients during pregnancy; can the changes during pregnancy in the gut microbiome be linked to disease activity/flares. | — |
Secondary
| Measure | Time frame |
|---|---|
| - to analyze the effect of disease activity on pregnancy outcomes (gestational term, birth weight, congenital abnormalities, mode of delivery) - to identify risk factors for an adverse disease course during pregnancy and adverse pregnancy outcomes - to analyze the effect of different IBD medication use, independent of disease activity, during pregnancy on pregnancy course and outcomes - to obtain data on the health of children born to IBD mothers (infections, allergies, growth) until 1 year and compare to children born to healthy mothers | — |
Contacts
Public ContactA. Lima, de
Erasmus MC
Outcome results
None listed