MRI investigation of blood flow and regulation to the brain by the neck vessels.

MR Imaging of cerebral blood flow and autoregulation in patients with steno-occlusive vertebro-basilar artery disease.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON28879

Enrollment

100

Registered

2010-09-30

Start date

2011-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

steno-occlusive disease of the vertebral and basilar artery.

Interventions

No intervention is applicable.

Eligibility

Inclusion criteria

Inclusion criteria: 1. 18 years or older; 2. Patients with ischaemic stroke or TIA in the perfusion territory of the vertebo-basilar arteries.

Exclusion criteria

Exclusion criteria: 1. Pregnancy or possible pregnancy; 2. Implanted stent(s); 3. Severe liver or renal dysfunction; 4. Addison’s disease; 5. Allergic reaction for sulfonamides; 6. Cor pulmonale; 7. Longobstruction / emfysema; 8. Primary hyperaldosteronisme; 9. Fenytoïne, primidon and/or fenobarbital use; 10. Japanese and Indian subjects or subjects of Japanese descent; 11. Impossibility to undergo MRI (claustrophobia, metal objects in or around the body).

Design outcomes

Primary

Measure	Time frame
The primary outcome is cerebrovascular reactivity measured with MR imaging at 3 Tesla using a visual stimulus and administration of vasodilatory challenge medication to induce hemodynamic stress.	—

Secondary

Measure	Time frame
Secondary outcomes include cerebral blood flow and perfusion territories of the brain feeding arteries.	—

Contacts

Public ContactN.S. Hartkamp

PO Box 85500

n.s.hartkamp@umcutrecht.nl+31 (0)88 7556687

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)