Sickle cell disease
Conditions
Interventions
Planned interventions will be checked, such as transfusion, but will not be done on behalf of this study
Sponsors
Amsterdam University Medical Centers, location AMC
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult (age = 18 years) SCD patients with high performance liquid chromatography (HPLC) confirmed diagnosis of HbSS, HbSß0-thalassemia, HbSC or HbSß+- thalassemia genotype 2. Willing and able to provide written informed consent 3. For the steady state/transfusion subgroup: visiting outpatient clinic with planned blood withdrawal 4. For the subgroup of patients during painful crisis: inclusion should be performed within 24 hours of admission to the hospital
Exclusion criteria
Exclusion criteria: 1. Unable to sign informed consent 2. VOC within 4 weeks of the outpatient clinic visit (steady state subgroup) 3. Pregnancy, self-reported 4. Active cancer, self-reported 5. Chronic (HIV) infection, self-reported 6. Use of immunosuppressive drugs, self-reported
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutrophil phenotypes | — |
Secondary
| Measure | Time frame |
|---|---|
| Neutrophil activity Neutrophil-platelet aggregates Neutrophil adhesion Neutrophil migration | — |
Contacts
Public ContactAafke Gaartman
Amsterdam University Medicalcenter, location AMC
Outcome results
None listed