Chronic heart failure exercise intolerance central hemodynamics
Conditions
Interventions
HIT is performed 3 times a week during 12 weeks and consists of 4 intervals of 4 minutes cycling on a ergometer at 85-95% of the peak aerobic capacity (peak Vo2) separated by 3 minute active pauses. T
Sponsors
Maxima Medical Centre (board of directors)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Written informed consent; 2. Systolic heart failure due to ischemic cardiomyopathy (due to one or more myocardial infarction, as confirmed with echocardiography) or dilating cardiomyopathy (no history of myocardial infarction, no proven ischemia, no congenital heart disease en no severe valve disorder); 3. Left ventricular ejection fraction (LVEF) ≤ 40% (assessed within 3 months before inclusion by echocardiography, MRI or radionuclear measurement); 4. New York Heart Association (NYHA) class II or III; 5. Optimal medical treatment.
Exclusion criteria
Exclusion criteria: 1. Myocardial infarction or unstable angina less than 3 months prior to inclusion; 2. Clinical signs of decompensated heart failure; 3. Ventricular tachycardia or ischemia during exercise; 4. Participation in a training program (≥2/week) in the last year; 5. Intracardiac shunts or congenital heart disease limiting exercise capacity; 6. Orthopaedic, vascular, pulmonary, neuromuscular and other disease limiting exercise capacity in a way that the training program is not feasible; 7. Pathological Allen test, In case no sufficient collateral circulation to the hand, in case of radial artery cannulation; 8. General contra indication for MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Training induced changes in resting cardiac output as determined by cMRI; 2. Correlation between training induced changes in resting cardiac output and cardiac output during maximal exercise (LiDCO). | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between training induced changes in resting c.q. exercizing cardiac output and changes in the following variables: 1. Cardiac size at rest (cMRI); 2. Cardiac output onset and recovery kinetics at submaximal exercise (LiDCO); 3. Recovery kinetics of muscle tissue oxygenation after submaximal exercise (Near Infrared Spectroscopy). | — |
Contacts
Public ContactR.F. Spee
De Run 4600
Outcome results
None listed