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STRAP – STudy to Reduce Antibiotic prescription in childhood Pneumonia

Study to Reduce Antibiotic prescription in children Pneumonia: implementation of a validated decision rule to target antibiotic prescription in children with suspected community acquired pneumonia.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON28856
Enrollment
1100
Registered
2015-07-23
Start date
2015-10-01
Completion date
Unknown
Last updated
2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

children

Interventions

-Feverkidstool: a clinical decision rule that assess the individual risk for pneumonia in children with fever -a risk based strategy for treatment advice (discharge, watchfull waiting, or antibiotics

Sponsors

Erasmus MC - Sophia
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: children aged 1 month – 5 years with fever (parent reported and/or measured during physical examination T >38°C) with signs suspected of community acquired pneumonia (CAP)

Exclusion criteria

Exclusion criteria: -febrile children with antibiotic treatment during the week prior to the ED visit -children with comorbidity, i.e. hemodynamic relevant cardiac disease, pulmonary, neurologic disease or (primary of secondary) immunodeficiency -children with an obvious single other infectious focus (cutaneous, otitis media, rhinitis), those with signs of complicated pneumonia at the moment of presentation (i.e. respiratory failure, pleura empyema, pneumothorax, suspicion of septicaemia), those with (self-reported) intolerance of amoxicillin, and those with suspicion of resistant pathogens due to a visit to foreign countries 2 months prior to the ED visit -patients not understanding or not able to act on safety-net instructions (due to language problems or logistics) in case of deterioration

Design outcomes

Primary

MeasureTime frame
Number of (narrow-spectrum) antibiotic prescriptions and its percentage within the total included population (benefit); Strategy failures (children with complications of CAP within 7 days) (safety).

Secondary

MeasureTime frame
-Compliance to the advice of the feverkidstool; percentage and number of narrow versus broad-spectrum antibiotic prescriptions; Duration and dosages of antibiotic prescriptions -Safety: Number of complications of pneumonia, association of isolated pathogens with complicated CAP course

Contacts

Public ContactR. Oostenbrink

P.O.box 2060

r.oostenbrink@erasmusmc.nl+ 31 (0)10 7036661

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)