Aneurysmal subarachnoid haemorrhage, hydrocephalus, intraventricular haemorrhage.
Conditions
Interventions
1. Placement of external ventricular drain (standard procedure)
2. Clipping / Coiling of ruptured aneurysm (standard procedure)
3. Infusion of rt-PA or placebo through external ventricular drain.
Sponsors
University Medical Center Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: 1. First or recurrent aneurysmal subarachnoid haemorrhage with intraventricular extension of the haemorrhage; 2. The ventricles must be enlarged and the intraventricular haemorrhage must be severe (Graeb-score more than 6); 3. Patients must be in a poor neurological condition, WFNS < 7 or WFNS < 6 in intubated patients.
Exclusion criteria
Exclusion criteria: 1. Other cause for intraventricular haemorrhage than a subarachnoid haemorrhage from a ruptured intracranial aneurysm; 2. Absence of both pupillary light reflexes; 3. Use of oral anticoagulants; 4. Treating physicians propose a palliative instead of curative treatment strategy; 5. Absence of informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death or dependency 6 months after subarachnoid haemorrhage. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Recurrent haemorrhage; 2. Secondary ischaemia; 3. Hydrocephalus; 4. Bleeding complications from fibrinolysis; 5. Death within 6 months; 6. Rankin 0 versus Rankin 1-5 and death. | — |
Contacts
Public ContactD. Nieuwkamp
University Medical Center Utrecht (UMCU), Department of Neurology, Heidelberglaan 100
Outcome results
None listed